Journal article
Perceived versus predicted risks of colorectal cancer and self-reported colonoscopies by members of mismatch repair gene mutation-carrying families who have declined genetic testing
L Flander, A Speirs-Bridge, A Rutstein, H Niven, AK Win, D Ait Ouakrim, JL Hopper, F Macrae, L Keogh, C Gaff, M Jenkins
Journal of Genetic Counseling | WILEY | Published : 2014
Abstract
People carrying germline mutations in mismatch repair genes are at high risk of colorectal cancer (CRC), yet about half of people from mutation-carrying families decline genetic counselling and/or testing to identify mutation status. We studied the association of quantitative measures of risk perception, risk prediction and self-reported screening colonoscopy in this elusive yet high-risk group. The sample of 26 participants (mean age 43.1 years, 14 women) in the Australasian Colorectal Cancer Family Registry were relatives of mutation carriers; had not been diagnosed with any cancer at the time of recruitment and had declined an invitation to attend genetic counselling and/or testing. A str..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by the Victorian Cancer Agency under #EO109-33, National Cancer Institute, National Institutes of Health under RFA #CA-95-011, and through cooperative agreements with the Australasian Colorectal Cancer Family Registry (U01 CA097735). Mark Jenkins is supported as a Senior Research Fellow by the National Health & Medical Research Council, Australia. Driss Ait Ouakrim was supported by an Australian Commonwealth Scientific and Industrial Research Organisation PhD scholarship (CSIRO, Preventative Heath Flagship). Aung Ko Win is supported by a grant from the Cancer Council Victoria and the Picchi Brothers Foundation, Australia. Authors have full control of all primary data and agree to review if requested.